MMRSA Guide
Microscopic illustration of MRSA (Staphylococcus aureus) bacteria
Reference · Clinical documentation & coding

MRSA ICD-10 codes

There is no single ICD-10 code for MRSA. Which code you assign depends on whether MRSA is causing a documented condition, is an infection with no stated site, or is colonisation found on a screening swab — and the sequencing rules matter as much as the codes.

Written by David Roberts, editor · Updated

Checked against current CDC and IDSA guidance. Not medically reviewed. How we source this

The short answer

In ICD-10-CM, B95.62 identifies MRSA as the cause of a condition coded elsewhere and is always a secondary code. A49.02 is for a MRSA infection with no documented site or condition. Z22.322 is for carrier status — colonisation, not infection. Pneumonia and sepsis have their own combination codes (J15.212 and A41.02) that already include the organism.

This page is written for coders, clinical documentation specialists and billing staff. If you are looking for the condition itself, start with MRSA symptoms or MRSA treatment.

MRSA code reference table

CodeDescriptionWhen to use it
B95.62Methicillin resistant Staphylococcus aureus infection as the cause of diseases classified elsewhereThe workhorse code. Assign it as an additional code after the code for the infection itself — cellulitis, abscess, wound infection, osteomyelitis, bacteraemia. Never sequence it first.
B95.61Methicillin susceptible Staphylococcus aureus infection as the cause of diseases classified elsewhereThe MSSA counterpart of B95.62, used the same way when susceptibility testing shows the isolate is not methicillin resistant.
A49.02Methicillin resistant Staphylococcus aureus infection, unspecified siteOnly when the documentation records a MRSA infection but no site and no specific condition. If a site or condition is documented, code that condition plus B95.62 instead.
A49.01Methicillin susceptible Staphylococcus aureus infection, unspecified siteThe MSSA equivalent of A49.02, subject to the same restriction.
Z22.322Carrier or suspected carrier of methicillin resistant Staphylococcus aureusColonisation, not infection — a positive screening swab in someone with no signs of infection. Do not assign it alongside an active MRSA infection code for the same encounter.
Z22.321Carrier or suspected carrier of methicillin susceptible Staphylococcus aureusMSSA colonisation, including routine nasal screening results.
J15.212Pneumonia due to methicillin resistant Staphylococcus aureusA combination code: it captures both the pneumonia and the organism, so no additional B95.62. J15.211 is the MSSA version.
A41.02Sepsis due to methicillin resistant Staphylococcus aureusAnother combination code — do not add B95.62. Add codes for any acute organ dysfunction (R65.20 / R65.21) when severe sepsis is documented. A41.01 is the MSSA version.
R78.81BacteremiaFor a positive blood culture without documented sepsis. Add B95.62 to identify MRSA as the organism.
L02.- / L03.-Cutaneous abscess, furuncle and carbuncle / cellulitisSite-specific skin codes. Sequence the skin code first, then B95.62 to name the organism.
T81.4-Infection following a procedureSurgical-site infection, with the appropriate seventh character, plus a code for the specific infection and B95.62 for the organism.
Z16.11Resistance to penicillinsNot used with MRSA codes. Resistance is already built into B95.62, A49.02 and the combination codes, so adding a Z16 code duplicates it.

Codes shown are ICD-10-CM, the United States clinical modification. Always verify against the current official code set and guidelines for the encounter's date of service.

The three sequencing rules that cause most errors

  • B95.62 never goes first. It is an "as the cause of diseases classified elsewhere" code, so the condition — the abscess, cellulitis, osteomyelitis, wound infection or bacteraemia — is sequenced first.
  • Do not pair A49.02 with B95.62. A49.02 is for a MRSA infection with no documented site. Once a site or condition is documented, that condition plus B95.62 replaces it.
  • Combination codes stand alone. J15.212 (MRSA pneumonia) and A41.02 (MRSA sepsis) already name the organism, so adding B95.62 duplicates it.

Infection vs colonisation

The distinction decides between an infection code and Z22.322. A positive nasal or skin swab in a patient with no clinical signs is colonisation, coded as carrier status. Documented signs of infection — purulence, spreading erythema, fever, a positive culture from a clinical specimen — move the encounter to an infection code. Where the record shows both a treated infection and separately documented ongoing carriage, follow payer and facility guidance and query the physician rather than assuming.

How the underlying swabs and cultures work is covered on MRSA testing, and the susceptibility result that separates MRSA from MSSA is explained on MSSA vs MRSA.

Worked examples

  • MRSA cellulitis of the left lower leg — L03.116 (cellulitis of left lower limb) followed by B95.62.
  • MRSA abscess of the right axilla — L02.413 (cutaneous abscess of right axilla) followed by B95.62.
  • MRSA ventilator-associated pneumonia — J95.851 (ventilator-associated pneumonia) with J15.212 to identify the pneumonia due to MRSA.
  • Severe sepsis due to MRSA with acute kidney injury — A41.02, then R65.20, then N17.9.
  • Positive MRSA screening swab, no infection — Z22.322 alone.
  • MRSA bacteraemia from an infected central line — T80.211- (bloodstream infection due to central venous catheter), R78.81 and B95.62 as documentation supports.

The clinical picture behind these examples is described on MRSA bacteraemia, MRSA pneumonia and MRSA sepsis.

Documentation that makes coding straightforward

  • The specific condition and anatomical site, with laterality.
  • Whether MRSA reflects infection or colonisation, stated explicitly.
  • The organism as reported by the laboratory, and whether it is methicillin resistant or susceptible.
  • For sepsis, a clear statement of sepsis or severe sepsis and each associated organ dysfunction.
  • For post-procedural infection, the relationship to the procedure and the device involved.

ICD-10 vs ICD-10-CM vs ICD-11

WHO's ICD-10 carries no MRSA-specific code; the B95.6 category simply identifies Staphylococcus aureus as a cause. The resistance-specific codes above are ICD-10-CM, the version used in the United States. ICD-11, in use in a growing number of countries, handles resistance through separate extension codes rather than the fifth-character split used in ICD-10-CM.

Frequently asked questions

What is the ICD-10 code for MRSA?
It depends on what is documented. B95.62 is used as an additional code when MRSA is the cause of an infection coded elsewhere, such as cellulitis or a wound infection. A49.02 is used when a MRSA infection is documented with no site and no specific condition. Z22.322 is used for MRSA colonisation or carrier status rather than infection.
What is the difference between B95.62 and A49.02?
B95.62 is a secondary code that names MRSA as the organism causing a condition coded elsewhere, so it always follows another code. A49.02 stands alone and is reserved for a documented MRSA infection with no specified site or condition. Assigning both for the same infection is incorrect.
What is the ICD-10 code for MRSA colonization?
Z22.322, carrier or suspected carrier of methicillin resistant Staphylococcus aureus. It applies to a positive screening swab in someone without signs of infection. Z22.321 is the equivalent for MSSA carriage.
Can you code Z22.322 and B95.62 together?
Not for the same encounter when there is an active MRSA infection. If the patient has a MRSA infection, code the infection and B95.62 (or the relevant combination code). Carrier status is coded only when colonisation is documented without infection.
What is the ICD-10 code for MRSA pneumonia?
J15.212. It is a combination code covering both the pneumonia and MRSA as the organism, so B95.62 is not added. J15.211 is pneumonia due to MSSA.
What is the ICD-10 code for MRSA sepsis?
A41.02, sepsis due to methicillin resistant Staphylococcus aureus. Because it is a combination code, B95.62 is not assigned in addition. If severe sepsis is documented, add R65.20 or R65.21 with codes for the specific organ dysfunctions.
How do you code a MRSA wound or skin infection?
Sequence the condition first — the specific abscess, cellulitis or wound infection code, including the site — then add B95.62 to identify MRSA. For a post-procedural wound infection, the T81.4- series is used with the appropriate additional codes.
Should Z16.11 be added to show antibiotic resistance?
No. The MRSA codes already convey methicillin resistance, so adding Z16.11 for resistance to penicillins duplicates that information. Z16 codes are for resistance not already captured by the infection code.
Is there a single ICD-10 code for MRSA bacteremia?
No single combination code exists. Code R78.81 for bacteraemia and add B95.62 for MRSA. If the documentation supports sepsis rather than bacteraemia alone, A41.02 applies instead.

Symptoms hub

Overview of MRSA symptoms and day-by-day progression.

What does MRSA look like?

Bumps, boils, abscesses and cellulitis — every visual form.

MRSA rash

Does MRSA cause a rash? Look-alikes and how to tell them apart.

MRSA in the nose

Nasal carriage vs infection, swab testing and mupirocin treatment.

MRSA skin infection

Types, diagnosis, treatment, and when skin MRSA becomes dangerous.

MRSA boil

Deep, painful, pus-filled lumps and how they are drained.

MRSA cellulitis

Spreading deeper-skin infection and urgent warning signs.

MRSA folliculitis

Small pus-filled bumps around hair follicles and prevention.

MRSA pneumonia

Hospital, ventilator-associated and necrotising lung infection.

MRSA bacteremia

MRSA in the bloodstream — how it gets there and how it's treated.

MRSA sepsis

Can MRSA cause sepsis? Warning signs and survival rates.

Invasive MRSA

How MRSA reaches the bloodstream, lungs and bone.

MRSA test

PCR nasal swab, wound culture and susceptibility testing.

MSSA vs MRSA

Same bacterium, different antibiotic susceptibility.

Staph infection vs pimple

How to tell a normal pimple from a staph or MRSA skin lesion.

MRSA colonization

Carriers, nasal swabs, how long carriage lasts and when it is treated.

MRSA UTI

MRSA in the urinary tract — catheters, symptoms and treatment.

Scalded skin syndrome

The staph toxin illness that makes a child's skin blister and peel.

Can MRSA kill you?

Death rates by infection type, who is at risk and the warning signs.

Staph infection

Staphylococcus aureus infection overall — symptoms, spread and treatment.

What does a staph infection look like?

Every form on the skin, stage by stage, and the look-alikes.

Is a staph infection contagious?

How it spreads, how long for, and the school, work and sport rules.

Antibiotics for a staph skin infection

Which drugs cover staph and MRSA, course lengths and allergy options.

References
  1. CDC / National Center for Health Statistics. ICD-10-CM Official Guidelines for Coding and Reporting (2025)
  2. CMS. ICD-10-CM code files and tabular list (2025)
  3. WHO. ICD-10 international classification of diseases, 10th revision (2019)
  4. CDC. Methicillin-resistant Staphylococcus aureus (MRSA) clinical overview (2024)